Mitogen-activated protein kinase and its activator are regulated by hypertonic stress in Madin-Darby canine kidney cells.

@article{Itoh1994MitogenactivatedPK,
  title={Mitogen-activated protein kinase and its activator are regulated by hypertonic stress in Madin-Darby canine kidney cells.},
  author={Takahito Itoh and Atsushi Yamauchi and Akiko Miyai and Kenji Yokoyama and Takenobu Kamada and Norishi Ueda and Yasuhiro Fujiwara},
  journal={The Journal of clinical investigation},
  year={1994},
  volume={93 6},
  pages={2387-92}
}
Madin-Darby canine kidney cells behave like the renal medulla and accumulate small organic solutes (osmolytes) in a hypertonic environment. The accumulation of osmolytes is primarily dependent on changes in gene expression of enzymes that synthesize osmolytes (sorbitol) or transporters that uptake them (myo-inositol, betaine, and taurine). The mechanism by which hypertonicity increases the transcription of these genes, however, remains unclear. Recently, it has been reported that yeast mitogen… CONTINUE READING