Mitogen-activated protein kinase activation induces corticotrophin-releasing hormone gene expression in human placenta.

@article{Cheng2005MitogenactivatedPK,
  title={Mitogen-activated protein kinase activation induces corticotrophin-releasing hormone gene expression in human placenta.},
  author={You-Hong Cheng and Stuart Handwerger},
  journal={Life sciences},
  year={2005},
  volume={77 11},
  pages={
          1263-72
        }
}
Corticotropin-releasing hormone (CRH) gene expression in human placental cells is induced by activation of the cyclic AMP and protein kinase C signal transduction pathways, but the role of the mitogen-activated kinase (MAPK) pathway is unknown. In this study, we showed that the MAPK inhibitor, PD098059, causes a dose-dependent inhibition of placental CRH gene expression. In contrast, overexpression of RAF in human choriocarcinoma JEG cells stimulates CRH promoter activity by 15-fold, and the… CONTINUE READING