Mitogen-activated protein kinase activation in UV-induced signal transduction.

  title={Mitogen-activated protein kinase activation in UV-induced signal transduction.},
  author={Ann M. Bode and Ziming Dong},
  journal={Science's STKE : signal transduction knowledge environment},
  volume={2003 167},
Experimental evidence supported by epidemiological findings suggests that solar ultraviolet (UV) irradiation is the most important environmental carcinogen leading to the development of skin cancers. Because the ozone layer blocks UVC (wavelength, 180 to 280 nm) exposure, UVA (UVA I, 340 to 400 nm; UVA II, 320 to 340 nm) and UVB (280 to 320 nm) are probably the chief carcinogenic components of sunlight with relevance for human skin cancer. Substantial contributions to the elucidation of the… CONTINUE READING


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