Mitogen-activated protein kinase activation by hydrogen peroxide is mediated through tyrosine kinase-dependent, protein kinase C-independent pathways in vascular smooth muscle cells: upregulation in spontaneously hypertensive rats.

@article{Tabet2005MitogenactivatedPK,
  title={Mitogen-activated protein kinase activation by hydrogen peroxide is mediated through tyrosine kinase-dependent, protein kinase C-independent pathways in vascular smooth muscle cells: upregulation in spontaneously hypertensive rats.},
  author={Fatiha Tabet and Ernesto L Schiffrin and Rhian M Touyz},
  journal={Journal of hypertension},
  year={2005},
  volume={23 11},
  pages={
          2005-12
        }
}
OBJECTIVE To investigate the putative molecular mechanisms underlying mitogen-activated protein (MAP) kinase activation by hydrogen peroxide (H(2)O(2)) in vascular smooth muscle cells (VSMC) and to evaluate whether H(2)O(2)-induced actions are altered in VSMC from spontaneously hypertensive rats (SHR). METHOD VSMC from mesenteric arteries of Wistar-Kyoto rats (WKY) and SHR were stimulated with H(2)O(2) (2-30 min). The phosphorylation of extracellular signal-regulated kinases (ERK)1/2 and… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 24 CITATIONS

Similar Papers

Loading similar papers…