Mitogen-activated protein kinase-activated protein kinase 2-deficient mice show increased susceptibility to Listeria monocytogenes infection.

@article{Lehner2002MitogenactivatedPK,
  title={Mitogen-activated protein kinase-activated protein kinase 2-deficient mice show increased susceptibility to Listeria monocytogenes infection.},
  author={Martin Dominik Lehner and Frank Schwoebel and Alexey Kotlyarov and Marcel Leist and Matthias Gaestel and Thomas Hartung},
  journal={Journal of immunology},
  year={2002},
  volume={168 9},
  pages={4667-73}
}
Mitogen-activated protein kinase-activated protein kinase 2 (MK2) is one of several kinases activated through direct phosphorylation by p38 mitogen-activated protein kinase. MK2 regulates LPS-induced TNF mRNA translation, and targeted mutation of the MK2 gene renders mice more resistant to D-galactosamine plus LPS-induced liver damage. In the present study, we investigated the role of MK2 in immune defense against Listeria monocytogenes infection. MK2-deficient mice displayed diminished… CONTINUE READING

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