Mitogen-activated protein kinase/extracellular signal-regulated kinase signaling in activated T cells abrogates TRAIL-induced apoptosis upstream of the mitochondrial amplification loop and caspase-8.

@article{Sderstrm2002MitogenactivatedPK,
  title={Mitogen-activated protein kinase/extracellular signal-regulated kinase signaling in activated T cells abrogates TRAIL-induced apoptosis upstream of the mitochondrial amplification loop and caspase-8.},
  author={Thomas S S{\"o}derstr{\"o}m and Minna Poukkula and Tim H. Holmstr{\"o}m and Kaisa M. Heiskanen and John E. Eriksson},
  journal={Journal of immunology},
  year={2002},
  volume={169 6},
  pages={
          2851-60
        }
}
Fas ligand and TNF-related apoptosis-inducing ligand (TRAIL) induce apoptosis in many different cell types. Jurkat T cells die rapidly by apoptosis after treatment with either ligand. We have previously shown that mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) can act as a negative regulator of apoptosis mediated by the Fas receptor. In this study we examined whether MAPK/ERK can also act as a negative regulator of apoptosis induced by TRAIL. Activated… CONTINUE READING
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