Mitogen-Activated Protein Kinase Pathways Mediated by ERK, JNK, and p38 Protein Kinases

@article{Johnson2002MitogenActivatedPK,
  title={Mitogen-Activated Protein Kinase Pathways Mediated by ERK, JNK, and p38 Protein Kinases},
  author={Gary L. Johnson and Razvan Lapadat},
  journal={Science},
  year={2002},
  volume={298},
  pages={1911 - 1912}
}
Multicellular organisms have three well-characterized subfamilies of mitogen-activated protein kinases (MAPKs) that control a vast array of physiological processes. These enzymes are regulated by a characteristic phosphorelay system in which a series of three protein kinases phosphorylate and activate one another. The extracellular signal–regulated kinases (ERKs) function in the control of cell division, and inhibitors of these enzymes are being explored as anticancer agents. The c-Jun amino… 

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