Mitogen‐activated protein kinases and asthma

  title={Mitogen‐activated protein kinases and asthma},
  author={G. Pelaia and G. Cuda and A. Vatrella and L. Gallelli and M. Caraglia and M. Marra and A. Abbruzzese and M. Caputi and R. Maselli and F. Costanzo and S. Marsico},
  journal={Journal of Cellular Physiology},
  • G. Pelaia, G. Cuda, +8 authors S. Marsico
  • Published 2005
  • Medicine, Biology
  • Journal of Cellular Physiology
  • Mitogen‐activated protein kinases (MAPKs) are evolutionary conserved enzymes which play a key role in signal transduction mediated by cytokines, growth factors, neurotransmitters and various types of environmental stresses. In the airways, these extracellular stimuli elicit complex inflammatory and structural changes leading to the typical features of asthma including T cell activation, eosinophil and mast cell infiltration, as well as bronchial hyperresponsiveness and airway remodelling… CONTINUE READING

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    Publications referenced by this paper.
    Mitogen-Activated Protein Kinase Pathways Mediated by ERK, JNK, and p38 Protein Kinases
    • 3,569
    • Highly Influential
    • PDF
    Mammalian MAP kinase signalling cascades
    • 4,675
    • PDF
    A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
    • 3,320
    Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human.
    • 2,451
    • PDF
    Pharmacological inhibitors of MAPK pathways.
    • 430
    Interleukin-4 and Interleukin-13 Signaling Connections Maps
    • 357