Mitofusins deficiency elicits mitochondrial metabolic reprogramming to pluripotency

@article{Son2015MitofusinsDE,
  title={Mitofusins deficiency elicits mitochondrial metabolic reprogramming to pluripotency},
  author={M J Son and Y Kwon and Binna Seol and H S Choi and S. Ryu and Chulhee Choi and Yee Sook Cho},
  journal={Cell Death and Differentiation},
  year={2015},
  volume={22},
  pages={1957-1969}
}
Cell reprogramming technology has allowed the in vitro control of cell fate transition, thus allowing for the generation of highly desired cell types to recapitulate in vivo developmental processes and architectures. However, the precise molecular mechanisms underlying the reprogramming process remain to be defined. Here, we show that depleting p53 and p21, which are barriers to reprogramming, yields a high reprogramming efficiency. Deletion of these factors results in a distinct mitochondrial… CONTINUE READING