Mitofusin 2 ablation increases endoplasmic reticulum-mitochondria coupling.

@article{Filadi2015Mitofusin2A,
  title={Mitofusin 2 ablation increases endoplasmic reticulum-mitochondria coupling.},
  author={Riccardo Filadi and Elisa Greotti and Gabriele Turacchio and Alberto Luini and Tullio Pozzan and Paola Pizzo},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2015},
  volume={112 17},
  pages={
          E2174-81
        }
}
The organization and mutual interactions between endoplasmic reticulum (ER) and mitochondria modulate key aspects of cell pathophysiology. Several proteins have been suggested to be involved in keeping ER and mitochondria at a correct distance. Among them, in mammalian cells, mitofusin 2 (Mfn2), located on both the outer mitochondrial membrane and the ER surface, has been proposed to be a physical tether between the two organelles, forming homotypic interactions and heterocomplexes with its… CONTINUE READING

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