Mitoflash frequency in early adulthood predicts lifespan in Caenorhabditis elegans

@article{Shen2014MitoflashFI,
  title={Mitoflash frequency in early adulthood predicts lifespan in Caenorhabditis elegans},
  author={En-Zhi Shen and Chun-qing Song and Yuan Lin and Wenhong Zhang and Pei-Fang Su and Wen-yuan Liu and Pan Zhang and Jiejia Xu and Na Lin and Cheng Zhan and Xianhua Wang and Yu Shyr and Heping Cheng and Meng-Qiu Dong},
  journal={Nature},
  year={2014},
  volume={508},
  pages={128-132}
}
It has been theorized for decades that mitochondria act as the biological clock of ageing, but the evidence is incomplete. Here we show a strong coupling between mitochondrial function and ageing by in vivo visualization of the mitochondrial flash (mitoflash), a frequency-coded optical readout reflecting free-radical production and energy metabolism at the single-mitochondrion level. Mitoflash activity in Caenorhabditis elegans pharyngeal muscles peaked on adult day 3 during active reproduction… CONTINUE READING
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