Mitocryptide-2, a neutrophil-activating cryptide, is a specific endogenous agonist for formyl-peptide receptor-like 1.

@article{Seki2011Mitocryptide2AN,
  title={Mitocryptide-2, a neutrophil-activating cryptide, is a specific endogenous agonist for formyl-peptide receptor-like 1.},
  author={Tetsuo Seki and Akiyoshi Fukamizu and Yoshiaki Kiso and Hidehito Mukai},
  journal={Biochemical and biophysical research communications},
  year={2011},
  volume={404 1},
  pages={482-7}
}
Peptides simultaneously produced during maturation and degradation of peptidergic hormones and functional proteins have recently become a great interest because they display unpredictably different biological roles than the parent proteins. Namely, we discovered two novel functional cryptic peptides, mitocryptide-1 (MCT-1) and mitocryptide-2 (MCT-2), hidden in mitochondrial cytochrome c oxidase and cytochrome b, that efficiently induced neutrophilic migration and activation at nanomolar… CONTINUE READING