Mitochondrion: an emerging platform critical for host antiviral signaling.

  title={Mitochondrion: an emerging platform critical for host antiviral signaling.},
  author={Chen Wang and Xinyi Liu and Bo Wei},
  journal={Expert opinion on therapeutic targets},
  volume={15 5},
INTRODUCTION Toll-like receptors (TLRs) and cytoplasmic retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are the two major receptor systems for detecting RNA viruses. RLRs play essential roles within the cytosol of various cell types. The signaling pathways converge at the mitochondrial antiviral signalling protein (MAVS) on the outer membrane of mitochondria. Recent research has surprisingly shown that many mitochondrial intrinsic factors play novel functions in RLR signaling… CONTINUE READING