Mitochondrially targeted wild-type p53 suppresses growth of mutant p53 lymphomas in vivo

@article{Palacios2006MitochondriallyTW,
  title={Mitochondrially targeted wild-type p53 suppresses growth of mutant p53 lymphomas in vivo},
  author={Gustavo Palacios and Ute M. Moll},
  journal={Oncogene},
  year={2006},
  volume={25},
  pages={6133-6139}
}
The complex apoptotic functions of the p53 tumor suppressor are central to its antineoplastic activity in vivo. Besides its well-known action as a transcriptional activator of apoptotic genes, p53 exerts a direct proapoptotic role at the mitochondria via protein–protein interactions with Bcl2 family members, thus executing the shortest known circuitry of… CONTINUE READING