Mitochondrially targeted antioxidants for the treatment of cardiovascular diseases.

  title={Mitochondrially targeted antioxidants for the treatment of cardiovascular diseases.},
  author={S. P. Sivagnana Subramanian and Balaraman Kalyanaraman and Raymond Q. Migrino},
  journal={Recent patents on cardiovascular drug discovery},
  volume={5 1},
Oxidative stress resulting from imbalance between reactive oxygen species (ROS) generation and antioxidant mechanisms is important in the pathogenesis of cardiovascular diseases such as atherosclerosis, ischemic heart disease, heart failure, stroke, hypertension and diabetes. Paradoxically, antioxidant therapy such as vitamin E has not been shown on large randomized clinical trials to favorably affect clinical outcomes. Since mitochondria are involved not only with bioenergetics but also with… CONTINUE READING


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