Mitochondrial uncoupling reduces exercise capacity despite several skeletal muscle metabolic adaptations.

@article{Schlagowski2014MitochondrialUR,
  title={Mitochondrial uncoupling reduces exercise capacity despite several skeletal muscle metabolic adaptations.},
  author={Anna I Schlagowski and François Singh and Anne Laure Charles and Thanuja Gali Ramamoorthy and Fabrice Favret and François Piquard and Bernard G{\'e}ny and Joffrey Zoll},
  journal={Journal of applied physiology},
  year={2014},
  volume={116 4},
  pages={364-75}
}
The effects of mitochondrial uncoupling on skeletal muscle mitochondrial adaptation and maximal exercise capacity are unknown. In this study, rats were divided into a control group (CTL, n = 8) and a group treated with 2,4-dinitrophenol, a mitochondrial uncoupler, for 28 days (DNP, 30 mg·kg(-1)·day(-1) in drinking water, n = 8). The DNP group had a significantly lower body mass (P < 0.05) and a higher resting oxygen uptake (Vo2, P < 0.005). The incremental treadmill test showed that maximal… CONTINUE READING