Mitochondrial uncoupling protein 3 (UCP3) in skeletal muscle.

  title={Mitochondrial uncoupling protein 3 (UCP3) in skeletal muscle.},
  author={N. Tsuboyama-Kasaoka and O. Ezaki},
  journal={Frontiers in bioscience : a journal and virtual library},
Mitochondrial uncoupling protein (UCP), mitochondrial transporters, function as a proton channel and increase thermogenesis. UCP1 is expressed in brown adipose tissues (BAT), UCP2 is widely expressed in multiple tissues, while UCP3 is expressed in skeletal muscle. Thus, UCPs, especially UCP3, in skeletal muscles is a good candidates for prevention of obesity and diabetes. However, the role of UCP3 in skeletal muscle for energy expenditure and obesity has been controversial. There is some… Expand
Regulação da expressão gênica das UCP2 e UCP3 pela restrição energética,jejum e exercício físico
During food restriction and fasting, there is a decrease in the amount of body adipose tissue and increase in the plasmatic free fatty acid concentration, with up-regulation of the UCP2 and UCP3 in the muscle, and an increase in lipid oxidation. Expand
Skeletal muscle non-shivering thermogenesis as an attractive strategy to combat obesity.
The mechanisms of skeletal muscle NST, including SLN mediated SERCA pump futile cycling, SR-mitochondrial crosstalk and increased mitochondrial biogenesis, and thermogenesis induced by uncoupling proteins 3 (UCP3) are highlighted. Expand
Human uncoupling protein 2 and 3 genes are associated with obesity in Japanese
Whether there is an association between the UCP2/UCP3 locus and the obesity in the Japanese population when using a single nucleotide polymorphism (SNP)-based and haplotype-based case–control study with gender-specific analysis is examined. Expand
Putative role of palmitate and Akt signaling in attenuating skeletal muscle growth in the obese zucker rat
Data indicate that although disruptions in Akt signaling in muscles of the OZR may be responsible for the decrease in muscle mass through attenuated satellite cell activation and proliferation, increased apoptotic signaling does not appear to be a factor to explain the decrease muscle mass in the OzR compared to the LZR. Expand
Transcription regulators and hormones involved in the development of brown fat and white fat browning: transcriptional and hormonal control of brown/beige fat development.
The current understanding of the regulators and hormones that participate in the development of brown fat and white fat browning is summarized. Expand
Muscular response and adaptation to diabetes mellitus.
DM-induced changes in the skeletal muscle seem to be dependent on types and severity of DM as well as on muscle fibers, and the central mechanism underlying these changes is impaired insulin action inThe skeletal muscle. Expand
Association of UCP2 and UCP3 gene polymorphisms with serum high-density lipoprotein cholesterol among Korean women.
The association of 10 uncoupling protein (UCP) 2 and UCP3 polymorphisms with serum HDL cholesterol levels and atherogenic indexes among 658 Korean women is assessed. Expand
Expression of genes related to mitochondrial function in Nellore cattle divergently ranked on residual feed intake
The results suggest the use of TFAM and UCP2 as possible candidate gene markers in breeding programs designed to increase the feed efficiency of Nellore cattle. Expand
Aspectos actuales de la obesidad
La herencia determinaria el set point individual del contenido graso, el cual supondria del 65 al 75% of the tendencia heredada hacia the obesidad, es el denominado “genotipo ahorrador” de energia. Expand


UCP3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue.
The molecular cloning of a third uncoupling protein homologue, designated UCP3, is reported, which is a promising target for anti-obesity drug development aimed at increasing thermogenesis. Expand
Energy Metabolism in Uncoupling Protein 3 Gene Knockout Mice*
It is demonstrated that UCP3 has uncoupling activity and that its absence may lead to increased production of ROS, and the consequence of increased mitochondrial coupling in U CP3 KO mice on metabolism and the possible role of yet unidentified compensatory mechanisms, remains to be determined. Expand
Uncoupling protein-3 expression in skeletal muscle and free fatty acids in obesity
A role for muscle U CP3 in the metabolic adaptations to increases in fatty-acid supply is suggested, and the involvement of UCP3 in a compensatory mechanism linking obesity to increased muscle thermogenesis is suggested. Expand
Uncoupling protein 3 is reduced in skeletal muscle of NIDDM patients.
Results suggest that UCP-3 regulation may be altered in states of insulin resistance, and a positive correlation between U CP-3 expression and whole-body insulin-mediated glucose utilization rate was also noted. Expand
Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean
Evidence is provided that skeletal muscle UCP-3 has the potential to influence metabolic rate and glucose homeostasis in the whole animal by the creation of transgenic mice that overexpress human U CP-3 in skeletal muscle. Expand
Increased uncoupling protein-2 and -3 mRNA expression during fasting in obese and lean humans.
The similar induction of gene expression observed during fasting in lean and obese subjects shows that there is no major alteration of UCP2 and -3 gene regulation in adipose tissue and skeletal muscle of obese subjects and suggests a role for these proteins in the metabolic adaptation to fasting. Expand
Skeletal muscle uncoupling protein 3 expression is a determinant of energy expenditure in Pima Indians.
Results indicate that UCP-3 may be a determinant of energy expenditure and metabolic efficiency in Pima Indians. Expand
Increased adipose expression of the uncoupling protein-3 gene by thiazolidinediones in Wistar fatty rats and in cultured adipocytes.
UCP3 gene expression is upregulated by TZDs in the WAT and BAT in Wistar fatty rats, an obese model with leptin receptor defect, and that adipose UCP3Gene expression is increased in response to TZD in vitro. Expand
Uncoupling protein‐3: a new member of the mitochondrial carrier family with tissue‐specific expression
The novel UCP3 was 57% and 73% identical to human UCP1 and UCP2, respectively, highly skeletal muscle‐specific and its expression was unaffected by cold acclimation, suggesting this new member of the UCP family is a candidate protein for the modulation of the respiratory control in skeletal muscle. Expand
Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia
The discovery of a gene that codes for a novel uncoupling protein, designated UCP2, which has 59% amino-acid identity to UCP1, is reported, and properties consistent with a role in diabetes and obesity are described, suggesting that U CP2 has a unique role in energy balance, body weight regulation and thermoregulation and their responses to inflammatory stimuli. Expand