Mitochondrial tumour suppressors: a genetic and biochemical update

@article{Gottlieb2005MitochondrialTS,
  title={Mitochondrial tumour suppressors: a genetic and biochemical update},
  author={Eyal Gottlieb and Ian P. M. Tomlinson},
  journal={Nature Reviews Cancer},
  year={2005},
  volume={5},
  pages={857-866}
}
Since the discovery 5 years ago that the D-subunit of succinate dehydrogenase (SDHD) can behave as a classic tumour suppressor, other nuclear-encoded mitochondrial proteins (SDHB, SDHC and fumarate hydratase) have been implicated in tumour susceptibility. Mutations in these proteins are principally involved in familial predisposition to benign tumours, but the spectrum of inherited lesions is increasingly recognized to include malignant tumours, such as malignant phaeochromocytomas and renal… CONTINUE READING
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