Mitochondrial transport in processes of cortical neurons is independent of intracellular calcium.

@article{BeltrnParrazal2006MitochondrialTI,
  title={Mitochondrial transport in processes of cortical neurons is independent of intracellular calcium.},
  author={Luis Beltr{\'a}n-Parrazal and H{\'e}ctor E. L{\'o}pez-Vald{\'e}s and Kevin Christopher Brennan and Mauricio D{\'i}az-Mu{\~n}oz and Jean de Vellis and Andrew Charles},
  journal={American journal of physiology. Cell physiology},
  year={2006},
  volume={291 6},
  pages={C1193-7}
}
Mitochondria show extensive movement along neuronal processes, but the mechanisms and function of this movement are not clearly understood. We have used high-resolution confocal microscopy to simultaneously monitor movement of mitochondria and changes in intracellular [Ca(2+)] ([Ca(2+)](i)) in rat cortical neurons. A significant percentage (27%) of the total mitochondria in cortical neuronal processes showed movement over distances of >2 microM. The average velocity was 0.52 microm/s. The… CONTINUE READING
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