Mitochondrial translocation of human telomerase reverse transcriptase in cord blood mononuclear cells of newborns with gestational diabetes mellitus mothers.

@article{Li2014MitochondrialTO,
  title={Mitochondrial translocation of human telomerase reverse transcriptase in cord blood mononuclear cells of newborns with gestational diabetes mellitus mothers.},
  author={Ping Li and Yu Neng Tong and Huiming Yang and Shu Qin Zhou and Fei Xiong and Tingzhu Huo and Meng Mao},
  journal={Diabetes research and clinical practice},
  year={2014},
  volume={103 2},
  pages={310-8}
}
AIMS To better understand the role of oxidative stress in fetal programming, we assessed the hypothesis that the mitochondrial translocation of human telomerase reverse transcriptase (hTERT) could protect neonatal mitochondrial DNA (mtDNA) from oxidative damage during pregnancies complicated by gestational diabetes mellitus (GDM). METHODS 26 GDM mothers and 47 controls and their newborns were enrolled. The plasma levels of 8-isoprostaglandin F(2α) in maternal and cord blood were measured to… CONTINUE READING
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