Mitochondrial transcription factor A is a proinflammatory mediator in hemorrhagic shock

@inproceedings{Chaung2012MitochondrialTF,
  title={Mitochondrial transcription factor A is a proinflammatory mediator in hemorrhagic shock},
  author={Wayne W Chaung and Rongqian Wu and Youxin Ji and Weifeng Dong and Ping Wang},
  booktitle={International journal of molecular medicine},
  year={2012}
}
Endogenous molecules released by dying cells [i.e., damage-associated molecular patterns (DAMPs)] after trauma and severe blood loss can activate pattern recognition receptors, leading to a cascade of inflammatory responses and organ injury. Mitochondrial transcription factor A (TFAM) is a transcription factor for mitochondrial DNA. TFAM is structurally related to high mobility group box 1 (HMGB1), an important member of DAMPs. We, therefore, hypothesized that TFAM can be released into the… CONTINUE READING

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