Mitochondrial transcription and its regulation in mammalian cells.

  title={Mitochondrial transcription and its regulation in mammalian cells.},
  author={Jordi Asin-Cayuela and Claes M. Gustafsson},
  journal={Trends in biochemical sciences},
  volume={32 3},
Human mitochondria contain multiple copies of a small double-stranded DNA genome that encode 13 components of the electron-transport chain and RNA components that are needed for mitochondrial translation. The mitochondrial genome is transcribed by a specialized machinery that includes a monomeric RNA polymerase, the mitochondrial transcription factor A and one of the two mitochondrial transcription factor B paralogues, TFB1M or TFB2M. Today, the components of the basal transcription machinery… CONTINUE READING
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