Mitochondrial toxicity of nucleoside analogues in primary human lymphocytes.


OBJECTIVE To evaluate if nucleoside analogue reverse transcriptase inhibitors (NRTIs) and polymerase-gamma inhibitors deplete mitochondrial DNA (mtDNA) in cultured primary lymphocytes and if such depletion might be associated with functional defects. METHODS Primary peripheral blood CD4 and CD8 lymphocytes were purified from six healthy humans (three male… (More)


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