Mitochondrial therapeutics in Alzheimer's disease and Parkinson's disease

  title={Mitochondrial therapeutics in Alzheimer's disease and Parkinson's disease},
  author={Jake G. Hoekstra and Kathleen S. Montine and Jing Zhang and Thomas J. Montine},
  booktitle={Alzheimer's Research & Therapy},
In neurons, mitochondria serve a wide variety of processes that are integral to their function and survival. It is, therefore, not surprising that evidence of mitochondrial dysfunction is observed across numerous neurodegenerative diseases. Alzheimer's disease and Parkinson's disease are two such diseases in which aberrant mitochondrial activity is proposed to contribute to pathogenesis. Current therapies for each disease target various mechanisms, but few, if any, directly target improved… CONTINUE READING


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