Mitochondrial targeting with antioxidant peptide SS-31 prevents mitochondrial depolarization, reduces islet cell apoptosis, increases islet cell yield, and improves posttransplantation function.

@article{Thomas2007MitochondrialTW,
  title={Mitochondrial targeting with antioxidant peptide SS-31 prevents mitochondrial depolarization, reduces islet cell apoptosis, increases islet cell yield, and improves posttransplantation function.},
  author={Dolca A Thomas and Craig E Stauffer and Kesheng Zhao and Hua Yang and Vijay K. Sharma and Hazel H. Szeto and Manikkam Suthanthiran},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2007},
  volume={18 1},
  pages={213-22}
}
Apoptotic cell death is a defined pathway for islet cell demise, and mitochondrial dysfunction contributes to islet cell apoptosis. The hypothesis that the novel peptide D-Arg-2', 6'-dimethyltyrosine-Lys-Phe-NH2 (SS-31), previously shown to target inner mitochondrial membrane and prevent oxidative damage of neuronal cells and other cell types, optimizes… CONTINUE READING