Mitochondrial targeting of tBid/Bax: a role for the TOM complex?

  title={Mitochondrial targeting of tBid/Bax: a role for the TOM complex?},
  author={Martin A. Ott and Erik Norberg and Boris Zhivotovsky and Sten Orrenius},
  journal={Cell Death and Differentiation},
The release of pro-apoptotic proteins from the mitochondria is a key event in cell death signaling that is regulated by Bcl-2 family proteins. For example, cleavage of the BH3-only protein, Bid, by multiple proteases leads to the formation of truncated Bid that, in turn, promotes the insertion/oligomerization of Bax into the mitochondrial outer membrane, resulting in pore formation and the release of proteins residing in the intermembrane space. Bax, a monomeric protein in the cytosol is… CONTINUE READING