Mitochondrial-targeted antioxidants protect skeletal muscle against immobilization-induced muscle atrophy.

@article{Min2011MitochondrialtargetedAP,
  title={Mitochondrial-targeted antioxidants protect skeletal muscle against immobilization-induced muscle atrophy.},
  author={Kisuk Min and Ashley J. Smuder and Oh-Sung Kwon and Andreas N. Kavazis and Hazel H. Szeto and Scott K. Powers},
  journal={Journal of applied physiology},
  year={2011},
  volume={111 5},
  pages={1459-66}
}
Prolonged periods of muscular inactivity (e.g., limb immobilization) result in skeletal muscle atrophy. Although it is established that reactive oxygen species (ROS) play a role in inactivity-induced skeletal muscle atrophy, the cellular pathway(s) responsible for inactivity-induced ROS production remain(s) unclear. To investigate this important issue, we tested the hypothesis that elevated mitochondrial ROS production contributes to immobilization-induced increases in oxidative stress… CONTINUE READING
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Regulation of muscle atrophy in aging and disease.

Advances in experimental medicine and biology • 2010
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