Mitochondrial-targeted antioxidants protect skeletal muscle against immobilization-induced muscle atrophy.

  title={Mitochondrial-targeted antioxidants protect skeletal muscle against immobilization-induced muscle atrophy.},
  author={Kisuk Min and Ashley J. Smuder and Oh-Sung Kwon and Andreas N. Kavazis and Hazel H. Szeto and Scott K. Powers},
  journal={Journal of applied physiology},
  volume={111 5},
Prolonged periods of muscular inactivity (e.g., limb immobilization) result in skeletal muscle atrophy. Although it is established that reactive oxygen species (ROS) play a role in inactivity-induced skeletal muscle atrophy, the cellular pathway(s) responsible for inactivity-induced ROS production remain(s) unclear. To investigate this important issue, we tested the hypothesis that elevated mitochondrial ROS production contributes to immobilization-induced increases in oxidative stress… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 23 times. VIEW TWEETS


Publications citing this paper.
Showing 1-10 of 63 extracted citations

Impaired Mitochondrial Energetics Characterize Poor Early Recovery of Muscle Mass Following Hind Limb Unloading in Old Mice

The journals of gerontology. Series A, Biological sciences and medical sciences • 2018
View 1 Excerpt


Publications referenced by this paper.
Showing 1-10 of 29 references

Regulation of muscle atrophy in aging and disease.

Advances in experimental medicine and biology • 2010
View 1 Excerpt

Similar Papers

Loading similar papers…