Mitochondrial-targeted Signal transducer and activator of transcription 3 (STAT3) protects against ischemia-induced changes in the electron transport chain and the generation of reactive oxygen species.

@article{Szczepanek2011MitochondrialtargetedST,
  title={Mitochondrial-targeted Signal transducer and activator of transcription 3 (STAT3) protects against ischemia-induced changes in the electron transport chain and the generation of reactive oxygen species.},
  author={Karol Szczepanek and Qun Chen and Marta Derecka and Fadi N. Salloum and Qifang Zhang and Magdalena Szelag and Joanna Cichy and Rakesh C. Kukreja and J{\'o}zef Dulak and Edward Joseph Lesnefsky and Andrew C Larner},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 34},
  pages={29610-20}
}
Expression of the STAT3 transcription factor in the heart is cardioprotective and decreases the levels of reactive oxygen species. Recent studies indicate that a pool of STAT3 resides in the mitochondria where it is necessary for the maximal activity of complexes I and II of the electron transport chain. However, it has not been explored whether mitochondrial STAT3 modulates cardiac function under conditions of stress. Transgenic mice with cardiomyocyte-specific overexpression of mitochondria… CONTINUE READING
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