Mitochondrial susceptibility to oxidative stress exacerbates cerebral infarction that follows permanent focal cerebral ischemia in mutant mice with manganese superoxide dismutase deficiency.

Abstract

Mitochondrial injury has been implicated in ischemic neuronal injury. Mitochondria, producing adenosine triphosphate by virtue of electron flow, have been shown to be both the sites of superoxide anion (O2-) production and the target of free radical attacks. We evaluated these mechanisms in an in vivo cerebral ischemia model, using mutant mice with a… (More)

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@article{Murakami1998MitochondrialST, title={Mitochondrial susceptibility to oxidative stress exacerbates cerebral infarction that follows permanent focal cerebral ischemia in mutant mice with manganese superoxide dismutase deficiency.}, author={Keiko Murakami and T Kondo and Masaya Kawase and Y Li and Shin Sato and S. F. Chen and Pak Hoo Chan}, journal={The Journal of neuroscience : the official journal of the Society for Neuroscience}, year={1998}, volume={18 1}, pages={205-13} }