Mitochondrial support of persistent presynaptic vesicle mobilization with age-dependent synaptic growth after LTP

@inproceedings{Smith2016MitochondrialSO,
  title={Mitochondrial support of persistent presynaptic vesicle mobilization with age-dependent synaptic growth after LTP},
  author={Heather L. Smith and Jennifer N Bourne and Guan Cao and Michael A. Chirillo and Linnaea E Ostroff and Deborah J. Watson and Kristen M Harris},
  booktitle={eLife},
  year={2016}
}
Mitochondria support synaptic transmission through production of ATP, sequestration of calcium, synthesis of glutamate, and other vital functions. Surprisingly, less than 50% of hippocampal CA1 presynaptic boutons contain mitochondria, raising the question of whether synapses without mitochondria can sustain changes in efficacy. To address this question, we analyzed synapses from postnatal day 15 (P15) and adult rat hippocampus that had undergone theta-burst stimulation to produce long-term… CONTINUE READING
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