Mitochondrial sirtuins in the rat adrenal gland: location within the glands of males and females, hormonal and developmental regulation of gene expressions.

@article{Celichowski2015MitochondrialSI,
  title={Mitochondrial sirtuins in the rat adrenal gland: location within the glands of males and females, hormonal and developmental regulation of gene expressions.},
  author={Piotr Celichowski and Karol Jopek and Marta Szyszka and Marianna Tyczewska and Ludwik Kazimierz Malendowicz and Marcin Rucinski},
  journal={Folia histochemica et cytobiologica},
  year={2015},
  volume={55 4},
  pages={
          190-202
        }
}
INTRODUCTION Sirtuins are NAD dependent class III histone deacetylases. In adrenal cortex mitochondria are able to transform - via nicotinamide nucleotide transhydrogenase (NNT) - NAD into NADPH, which is required for steroidogenesis. These findings suggest that sirtuins expressed in mitochondria, Sirt3, Sirt4 and Sirt5, may be associated with adrenal steroidogenesis. Therefore, the purpose of this study was to characterize the expression of mitochondrial sirtuins (Sirt3-5) in individual… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 56 REFERENCES

Nampt (visfatin) and hypothalamo-pituitary-adrenal (HPA) axis of the rat

PJK Celichowski, P Milecka, M Szyszka
  • Mol Med Rep (accepted to print),
  • 2017
VIEW 2 EXCERPTS

Role of Nicotinamide nucleotide transhydrogenase in the control of steroidogenesis in mouse adrenals

E. Meimaridou, V. Chortis, T Fragoulis
  • Endocrine Society’s 98th Annual Meeting and Expo. Boston, April
  • 2016
VIEW 1 EXCERPT