Mitochondrial sirtuins and their relationships with metabolic disease and cancer.

@article{Kumar2015MitochondrialSA,
  title={Mitochondrial sirtuins and their relationships with metabolic disease and cancer.},
  author={Sudarshan Kumar and David B Lombard},
  journal={Antioxidants & redox signaling},
  year={2015},
  volume={22 12},
  pages={
          1060-77
        }
}
SIGNIFICANCE Maintenance of metabolic homeostasis is critical for cellular and organismal health. Proper regulation of mitochondrial functions represents a crucial element of overall metabolic homeostasis. Mitochondrial sirtuins (SIRT3, SIRT4, and SIRT5) play pivotal roles in promoting this homeostasis by regulating numerous aspects of mitochondrial metabolism in response to environmental stressors. RECENT ADVANCES New work has illuminated multiple links between mitochondrial sirtuins and… CONTINUE READING
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