Mitochondrial signaling in the vascular endothelium: beyond reactive oxygen species

  title={Mitochondrial signaling in the vascular endothelium: beyond reactive oxygen species},
  author={Andrew O Kadlec and Andreas M Beyer and Karima Ait-Aissa and David D. Gutterman},
  journal={Basic Research in Cardiology},
Traditionally, the mitochondria have been viewed as the cell’s powerhouse, producing energy in the form of ATP. As a byproduct of ATP formation, the mitochondrial electron transport chain produces substantial amounts of reactive oxygen species (ROS). First thought to be toxic, recent literature indicates an important signaling function for mitochondria-derived ROS, especially in relation to cardiovascular disease pathogenesis. This has spawned an evolution to a more contemporary view of… CONTINUE READING
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