Mitochondrial signaling in cell death via the Bcl-2 family.

@article{Leibowitz2010MitochondrialSI,
  title={Mitochondrial signaling in cell death via the Bcl-2 family.},
  author={Brian J. Leibowitz and Jian Yu},
  journal={Cancer biology & therapy},
  year={2010},
  volume={9 6},
  pages={
          417-22
        }
}
Apoptosis is a critical process for the maintenance of tissue homeostasis and prevention of tumorigenesis. The members of the Bcl-2 family of proteins are the central regulators of the intrinsic apoptotic pathway. Within the Bcl-2 family, the BH3-only subfamily of proteins is tasked with sensing a broad range of apoptotic stimuli and transmitting this signal to other Bcl-2 proteins to initiate programmed cell death. This family of proteins is highly regulated at both transcriptional and post… CONTINUE READING

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