Mitochondrial respiratory function and cell death in focal cerebral ischemia.

@article{Anderson1999MitochondrialRF,
  title={Mitochondrial respiratory function and cell death in focal cerebral ischemia.},
  author={Michelle F. Anderson and Neil Sims},
  journal={Journal of neurochemistry},
  year={1999},
  volume={73 3},
  pages={1189-99}
}
Pyruvate-supported oxygen uptake was determined as a measure of the functional capacity of mitochondria obtained from rat brain during unilateral middle cerebral artery occlusion and reperfusion. During ischemia, substantial reductions developed in both ADP-stimulated and uncoupled respiration in tissue from the focus of the affected area in the striatum and cortex. A similar pattern of change but with lesser reductions was seen in the adjacent perifocal tissue. Succinate-supported respiration… CONTINUE READING
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