Mitochondrial respiratory function and cell death in focal cerebral ischemia.

  title={Mitochondrial respiratory function and cell death in focal cerebral ischemia.},
  author={Michelle F. Anderson and Neil Sims},
  journal={Journal of neurochemistry},
  volume={73 3},
Pyruvate-supported oxygen uptake was determined as a measure of the functional capacity of mitochondria obtained from rat brain during unilateral middle cerebral artery occlusion and reperfusion. During ischemia, substantial reductions developed in both ADP-stimulated and uncoupled respiration in tissue from the focus of the affected area in the striatum and cortex. A similar pattern of change but with lesser reductions was seen in the adjacent perifocal tissue. Succinate-supported respiration… CONTINUE READING
23 Citations
0 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 23 extracted citations

Similar Papers

Loading similar papers…