Mitochondrial respiratory-chain adaptations in macrophages contribute to antibacterial host defense

Abstract

Macrophages tightly scale their core metabolism after being activated, but the precise regulation of the mitochondrial electron-transport chain (ETC) and its functional implications are currently unknown. Here we found that recognition of live bacteria by macrophages transiently decreased assembly of the ETC complex I (CI) and CI-containing super-complexes… (More)
DOI: 10.1038/ni.3509

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