Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development.

  title={Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development.},
  author={Gerritje J. W. van der Windt and Bart Everts and Chih-Hao Chang and Jonathan D. Curtis and Tori C. Freitas and Eyal Amiel and Edward J. Pearce and Erika L Pearce},
  volume={36 1},
CD8(+) T cells undergo major metabolic changes upon activation, but how metabolism influences the establishment of long-lived memory T cells after infection remains a key question. We have shown here that CD8(+) memory T cells, but not CD8(+) T effector (Teff) cells, possessed substantial mitochondrial spare respiratory capacity (SRC). SRC is the extra capacity available in cells to produce energy in response to increased stress or work and as such is associated with cellular survival. We found… CONTINUE READING
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