Mitochondrial respiration and respiration-associated proteins in cell lines created through Parkinson's subject mitochondrial transfer.

@article{Esteves2010MitochondrialRA,
  title={Mitochondrial respiration and respiration-associated proteins in cell lines created through Parkinson's subject mitochondrial transfer.},
  author={Ana Raquel Esteves and Jane Wei‐zhen Lu and Mariana Rodova and Isaac G. Onyango and E Lezi and Richard Nickolas Dubinsky and Kelly E. Lyons and Rajesh Pahwa and Jeffrey M. Burns and Sandra M Cardoso and Russell H Swerdlow},
  journal={Journal of neurochemistry},
  year={2010},
  volume={113 3},
  pages={
          674-82
        }
}
Parkinson's disease (PD) is associated with perturbed mitochondrial function. Studies of cytoplasmic hybrid (cybrid) cell lines containing mitochondria from PD subjects suggest complex I dysfunction in particular is a relatively upstream biochemical defect. To evaluate potential downstream consequences of PD mitochondrial dysfunction, we used a cybrid approach to model PD mitochondrial dysfunction; our cybrid cell lines were generated via transfer of PD or control subject platelet mitochondria… CONTINUE READING

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