Mitochondrial replacement therapy in reproductive medicine.

  title={Mitochondrial replacement therapy in reproductive medicine.},
  author={Don P Wolf and Nargiz Mitalipov and Shoukhrat Mitalipov},
  journal={Trends in molecular medicine},
  volume={21 2},
Mitochondrial dysfunction is implicated in disease and age-related infertility. Mitochondrial replacement therapies (MRT) in oocytes or zygotes, such as pronuclear (PNT), spindle (ST), or polar body (PBT) transfer, could prevent second-generation transmission of mitochondrial DNA (mtDNA) defects. PNT, associated with high levels of mtDNA carryover in mice but low levels in human embryos, carries ethical issues secondary to donor embryo destruction. ST, developed in primates, supports normal… CONTINUE READING
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