Mitochondrial replacement in human oocytes carrying pathogenic mitochondrial DNA mutations

  title={Mitochondrial replacement in human oocytes carrying pathogenic mitochondrial DNA mutations},
  author={Eunju Kang and Jun Wu and Nuria Marti Gutierrez and Amy Koski and Rebecca Tippner-Hedges and Karen Agaronyan and Aida Platero-Luengo and Paloma Mart{\'i}nez-Redondo and Hong Ma and Yeonmi Lee and Tomonari Hayama and Crystal Van Dyken and Xinjian Wang and Shiyu Luo and Riffat Ahmed and Ying Li and Dongmei Ji and Refik Kayali and Cengiz Cinnioglu and Susan Olson and Jeffrey T Jensen and David Battaglia and David M Lee and Diana H. Wu and Taosheng Huang and Don P Wolf and Dmitry Temiakov and Juan Carlos Izpisua Belmonte and Paula Amato and Shoukhrat Mitalipov},
Maternally inherited mitochondrial (mt)DNA mutations can cause fatal or severely debilitating syndromes in children, with disease severity dependent on the specific gene mutation and the ratio of mutant to wild-type mtDNA (heteroplasmy) in each cell and tissue. Pathogenic mtDNA mutations are relatively common, with an estimated 778 affected children born each year in the United States. Mitochondrial replacement therapies or techniques (MRT) circumventing mother–to–child mtDNA disease… CONTINUE READING
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