Mitochondrial release of AIF and EndoG requires caspase activation downstream of Bax/Bak-mediated permeabilization.

@article{Arnoult2003MitochondrialRO,
  title={Mitochondrial release of AIF and EndoG requires caspase activation downstream of Bax/Bak-mediated permeabilization.},
  author={Damien Arnoult and Brigitte R Gaume and Mariusz Karbowski and Juanita C Sharpe and Francesco Cecconi and Richard J Youle},
  journal={The EMBO journal},
  year={2003},
  volume={22 17},
  pages={4385-99}
}
Mitochondrial outer-membrane permeabilization by pro-apoptotic Bcl-2 family members plays a crucial role in apoptosis induction. However, whether this directly causes the release of the different mitochondrial apoptogenic factors simultaneously is currently unknown. Here we report that in cells or with isolated mitochondria, pro-apoptotic Bcl-2 proteins cause the release of cytochrome c, Smac/Diablo and HtrA2/Omi but not endonuclease G (EndoG) and apoptosis-inducing factor (AIF). In cells… CONTINUE READING
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