Mitochondrial regulation of cell death.

  title={Mitochondrial regulation of cell death.},
  author={Stephen W G Tait and Douglas R Green},
  journal={Cold Spring Harbor perspectives in biology},
  volume={5 9}
Although required for life, paradoxically, mitochondria are often essential for initiating apoptotic cell death. Mitochondria regulate caspase activation and cell death through an event termed mitochondrial outer membrane permeabilization (MOMP); this leads to the release of various mitochondrial intermembrane space proteins that activate caspases, resulting in apoptosis. MOMP is often considered a point of no return because it typically leads to cell death, even in the absence of caspase… CONTINUE READING
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