Mitochondrial regulation of caspase activation by cytochrome oxidase and tetramethylphenylenediamine via cytosolic cytochrome c redox state.

@article{Borutait2007MitochondrialRO,
  title={Mitochondrial regulation of caspase activation by cytochrome oxidase and tetramethylphenylenediamine via cytosolic cytochrome c redox state.},
  author={Vilmantė Borutaitė and Guy C Brown},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 43},
  pages={31124-30}
}
Cytochrome c release from mitochondria induces caspase activation in cytosols; however, it is unclear whether the redox state of cytosolic cytochrome c can regulate caspase activation. By using cytosol isolated from mammalian cells, we find that oxidation of cytochrome c by added cytochrome oxidase stimulates caspase activation, whereas reduction of cytochrome c by added tetramethylphenylenediamine (TMPD) or yeast lactate dehydrogenase/cytochrome c reductase blocks caspase activation. Scrape… CONTINUE READING

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Cytochrome c Redox State Regulates Apoptosis 31130 JOURNAL OF BIOLOGICAL CHEMISTRY

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