Mitochondrial redox signaling enables repair of injured skeletal muscle cells

@article{Horn2017MitochondrialRS,
  title={Mitochondrial redox signaling enables repair of injured skeletal muscle cells},
  author={Adam Horn and Jack H Van der Meulen and Aurelia Defour and Marshall Hogarth and Sen Chandra Sreetama and Aaron Reed and Luana L. Scheffer and Navdeep S Chandel and Jyoti K Jaiswal},
  journal={Science Signaling},
  year={2017},
  volume={10}
}
Strain and physical trauma to mechanically active cells, such as skeletal muscle myofibers, injures their plasma membranes, and mitochondrial function is required for their repair. We found that mitochondrial function was also needed for plasma membrane repair in myoblasts as well as nonmuscle cells, which depended on mitochondrial uptake of calcium through the mitochondrial calcium uniporter (MCU). Calcium uptake transiently increased the mitochondrial production of reactive oxygen species… CONTINUE READING
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