Mitochondrial reactive oxygen species promote epidermal differentiation and hair follicle development.

@article{Hamanaka2013MitochondrialRO,
  title={Mitochondrial reactive oxygen species promote epidermal differentiation and hair follicle development.},
  author={Robert B Hamanaka and Andrea Glasauer and Paul Hoover and Shuangni Yang and Hanz Blatt and Andrew Mullen and Spiro Getsios and Cara J Gottardi and Ralph J DeBerardinis and Robert M Lavker and Navdeep S Chandel},
  journal={Science signaling},
  year={2013},
  volume={6 261},
  pages={ra8}
}
Proper regulation of keratinocyte differentiation within the epidermis and follicular epithelium is essential for maintenance of epidermal barrier function and hair growth. The signaling intermediates that regulate the morphological and genetic changes associated with epidermal and follicular differentiation remain poorly understood. We tested the hypothesis that reactive oxygen species (ROS) generated by mitochondria are an important regulator of epidermal differentiation by generating mice… CONTINUE READING
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