Mitochondrial reactive oxygen species production and elimination.

  title={Mitochondrial reactive oxygen species production and elimination.},
  author={Alexander G Nickel and Michael Kohlhaas and Christoph Maack},
  journal={Journal of molecular and cellular cardiology},
Reactive oxygen species (ROS) play an important role in cardiovascular diseases, and one important source for ROS are mitochondria. Emission of ROS from mitochondria is the net result of ROS production at the electron transport chain (ETC) and their elimination by antioxidative enzymes. Both of these processes are highly dependent on the mitochondrial redox state, which is dynamically altered under different physiological and pathological conditions. The concept of "redox-optimized ROS balance… CONTINUE READING
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