Mitochondrial reactive oxygen species and cancer

  title={Mitochondrial reactive oxygen species and cancer},
  author={Lucas B Sullivan and Navdeep S Chandel},
  booktitle={Cancer & metabolism},
Mitochondria produce reactive oxygen species (mROS) as a natural by-product of electron transport chain activity. While initial studies focused on the damaging effects of reactive oxygen species, a recent paradigm shift has shown that mROS can act as signaling molecules to activate pro-growth responses. Cancer cells have long been observed to have increased production of ROS relative to normal cells, although the implications of this increase were not always clear. This is especially… CONTINUE READING