Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release.

  title={Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release.},
  author={Dmitry B. Zorov and Magdalena Juhaszova and Steven J. Sollott},
  journal={Physiological reviews},
  volume={94 3},
Byproducts of normal mitochondrial metabolism and homeostasis include the buildup of potentially damaging levels of reactive oxygen species (ROS), Ca(2+), etc., which must be normalized. Evidence suggests that brief mitochondrial permeability transition pore (mPTP) openings play an important physiological role maintaining healthy mitochondria homeostasis. Adaptive and maladaptive responses to redox stress may involve mitochondrial channels such as mPTP and inner membrane anion channel (IMAC… CONTINUE READING
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