Mitochondrial reactive oxygen species: A double edged sword in ischemia/reperfusion vs preconditioning

  title={Mitochondrial reactive oxygen species: A double edged sword in ischemia/reperfusion vs preconditioning},
  author={Theodore J. Kalogeris and Yimin Bao and Ronald J. Korthuis},
  booktitle={Redox biology},
Reductions in the blood supply produce considerable injury if the duration of ischemia is prolonged. Paradoxically, restoration of perfusion to ischemic organs can exacerbate tissue damage and extend the size of an evolving infarct. Being highly metabolic organs, the heart and brain are particularly vulnerable to the deleterious effects of ischemia/reperfusion (I/R). While the pathogenetic mechanisms contributing to I/R-induced tissue injury and infarction are multifactorial, the relative… CONTINUE READING
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