Mitochondrial pyruvate transport: a historical perspective and future research directions.

@article{McCommis2015MitochondrialPT,
  title={Mitochondrial pyruvate transport: a historical perspective and future research directions.},
  author={Kyle S. McCommis and Brian N Finck},
  journal={The Biochemical journal},
  year={2015},
  volume={466 3},
  pages={443-54}
}
Pyruvate is the end-product of glycolysis, a major substrate for oxidative metabolism, and a branching point for glucose, lactate, fatty acid and amino acid synthesis. The mitochondrial enzymes that metabolize pyruvate are physically separated from cytosolic pyruvate pools and rely on a membrane transport system to shuttle pyruvate across the impermeable inner mitochondrial membrane (IMM). Despite long-standing acceptance that transport of pyruvate into the mitochondrial matrix by a carrier… CONTINUE READING

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